MTHFR and Mental Health

MTHFR and Mental Health

MTHFR Role in Mental Health

Methyl TetraHydroFolate Reductase (MTHFR) is a gene that produces an essential enzyme in the body. MTHFR plays a key role with regard to many aspects of physical and mental health.

Normally, the MTHFR gene produces enough of the related enzyme to perform its functions well.

One function that is important for mental health is the conversion of the essential B vitamin folate into a more usable L-methyl folate that enables our bodies to convert the amino acid homocysteine to another amino acid, methionine.

The body then uses methionine to make important proteins and other important compounds including important brain neuro-transmitters like:

  1. serotonin
  2. dopamine
  3. norepinephrine

Neurotransmitters are important for focus, concentration, mood and energy.

Low Serotonin

Low serotonin can be associated with the follow disorders:

  • PMS
  • migraine headaches
  • anxiety
  • depression

Low Dopamine

Low dopamine levels are associated with the following symptoms:

  • fatigue
  • low motivation
  • energy

In addition, enzymatic defects and elevation of homocysteine levels in the blood can lead to blood clots, recurrent miscarriages and heart disease.


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