I have an IUD (Mirena), this is my second one. It is due to come out next year. I was wondering what the correlation is between the IUD and depression? I have a history of depression, but it has gotten worse. I’m currently on 3 different antidepressants, which really are not helping.

When I think about it now, it seems to have increased since the time I had the second one placed 4 years ago. I know hormones can have an impact on mood/mental well-being. Do you think there is a connection between the two?


IUDs are not a cause of depression. IUDs affect the uterus locally and do not affect the neurotransmitters in the brain. Depression is common and treatable.

It is important for you to see your physician to get evaluated for thyroid status, vitamin D, blood count and then review medication and non-medication treatment of depression. You can certainly evaluate your type of contraception as there are many other options besides IUD.

It is important to get mood disorders treated with medication if needed, counseling, a healthy diet rich in omega-3s and daily exercise.

All my best,
Speaking of Women’s Health nurse

July 23, 2015 at 9:30am